Compounded Semaglutide vs. Compounded Tirzepatide: Your Guide to Weight Loss Solutions

Both compounded semaglutide and tirzepatide work by reducing hunger, increasing feelings of fullness, and improving metabolic health. When paired with a healthy diet and exercise, they can lead to significant, sustainable weight loss. Here’s how they differ:

• Compounded Semaglutide: Activates GLP-1 receptors to slow gastric emptying, helping you feel satisfied with smaller meals. It also curbs hunger signals in the brain, supporting adherence to a calorie-controlled plan.
• Compounded Tirzepatide: Combines GIP and GLP-1 receptor activation to suppress appetite and boost fat metabolism. This dual mechanism may result in more pronounced weight loss for some individuals.

Clinical studies on the base compounds (non-compounded versions) provide insight into their weight loss potential, and compounded versions are formulated to deliver similar benefits. Results vary based on dosing, lifestyle, and individual response:

• Compounded Semaglutide: Studies on semaglutide show an average weight loss of 15-17% of body weight over 68 weeks with weekly injections. For a 200-pound person, that’s about 30-40 pounds. Compounded versions aim to replicate these outcomes with tailored dosing.
• Compounded Tirzepatide: Research on tirzepatide indicates 20-25% body weight reduction over 72 weeks, or 40-50 pounds for a 200-pound individual. Compounded tirzepatide’s dual action may offer a slight edge for some users.

Our healthcare provider can adjust dosing to optimize results, making compounded medications a flexible option for personalized weight loss.

Both medications may cause similar side effects, primarily digestive, but compounded formulations can sometimes be adjusted to minimize discomfort:

• Common Side Effects: Nausea, diarrhea, vomiting, and constipation are most frequent, especially when starting treatment. These often decrease over time. Rare risks, like pancreatitis and thyroid concerns, should be discussed with your provider. Compounded medication can give you dosing flexibility, and can be adjusted to reduce side effects.

Compounded semaglutide and tirzepatide are prescription-only, administered via weekly injections. Unlike brand-name drugs, which can cost $1,000-$1,600 monthly, compounded versions are often more affordable, though prices vary based on the pharmacy and formulation. Additional benefits include:

• Customization: Dosing can be tailored to your needs, potentially improving tolerance and effectiveness.
• Availability: Compounded medications may be more accessible during shortages of brand-name drugs.
• Cost Savings: Compounded options are often less expensive, though insurance coverage may be limited.

Choosing between compounded semaglutide and tirzepatide depends on your health goals, medical history, and response to treatment. Consider these factors:

• Choose Compounded Semaglutide If: You want a proven option with a strong track record. It’s ideal for those seeking significant weight loss at a lower cost.
• Choose Compounded Tirzepatide If: You’re aiming for potentially greater weight loss, and not affected by the possible side effects and slight higher cost.

Our healthcare provider can help determine the best choice and customize your treatment plan. Pair these medications with a nutrient-rich diet, regular exercise, and healthy habits to maximize results.